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结直肠癌（Colo rectal cancer，CRC）是具有高发病率和高死亡率的恶性肿瘤之一，严重威胁人类的健康。现代医学常采用手术、放化疗等方式治疗结直肠癌，但仍存在明显不足，因此，寻找更安全有效的治疗方式尤为重要。腺苷酸活化蛋白激酶（AMPK）能通过调控细胞增殖、凋亡、迁移与侵袭等在结直肠癌中发挥作用，被认为是抗结直肠癌的重要靶点。研究发现，中药单体能通过调控AMPK信号通路发挥抗结直肠癌作用。本文通过对近几年来中药单体调控AMPK信号通路治疗结直肠癌的作用机制进行综述，以期为结直肠癌的中医药治疗提供参考。
Abstract：Colorectal cancer (CRC) is one of the most prevalent and lethal malignancies， posing a serious threat to human health. Modern medicine commonly employs surgery， radiotherapy and chemotherapy for CRC treatment， yet these approaches still have significant limitations. Therefore， finding safer and more effective therapeutic strategies is of great importance. The adenosine monophosphate-activated protein kinase (AMPK) plays a critical role in CRC by regulating cell proliferation， apoptosis， migration and invasion， making it a promising therapeutic target. Recent studies have shown that the active monomers isolated from traditional Chinese medicine (TCM) can exert anti-CRC effects by modulating the AMPK pathway. This article reviews the mechanisms by which TCM monomers regulate the AMPK signaling pathway in CRC treatment， aiming to provide insights for the application of TCM in combating colorectal cancer.
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基本信息:
中图分类号:R273
引用信息:
[1]刘雪,邹文萱,易飞扬,等.中药单体调控AMPK信号通路治疗结直肠癌的研究进展[J].现代中药研究与实践().
基金信息:
国家自然科学基金(81573990)
2026-05-15
2026-05-15
2026-05-15