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2025, 05, v.39 84-89
23-乙酰泽泻醇B抗衰老作用机制的研究进展
基金项目(Foundation): 2025年中医药事业传承和发展项目(YLB2025ZYYSY01); 2022山东省医药卫生科技发展计划项目(202216000995); 山东中医药大学附属医院第三批朝阳人才项目(zyrc-2024-22)
邮箱(Email): 173738895@qq.com;
DOI: 10.13728/j.1673-6427.2025.05.013
投稿时间: 2025-03-10
投稿日期(年): 2025
修回时间: 2025-04-17
终审时间: 2025-04-25
终审日期(年): 2025
审稿周期(年): 1
发布时间: 2025-10-28
出版时间: 2025-10-28
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摘要:

23-乙酰泽泻醇B作为中药泽泻的关键活性成分,近年来研究表明其通过抗氧化应激、抑制炎症反应、调控脂质代谢稳态及促进细胞再生与修复等多靶点机制,在延缓整体衰老和血管内皮功能退化中展现独特优势。同时,现有证据表明其兼具抗肿瘤活性,提示衰老与癌变的共同分子路径也可能成为新型研究切入点。通过系统综述该成分的多维度抗衰老机制,以期为其深入研究和临床转化评估提供参考。

Abstract:

As a key active ingredient in traditional Chinese medicine Alisma Rhizoma,Alisol B 23-acetate has been shown to exhibit unique advantages in delaying overall aging and endothelial dysfunction through multitarget mechanisms such as anti-oxidant stress,inhibition of inflammatory response,regulation of lipid metabolism homeostasis,and promotion of cell regeneration and repair.Meanwhile,existing evidence suggests that it possesses anti-tumor activity,suggesting that the common molecular pathway between aging and carcinogenesis may also become a new research entry point.By systematically reviewing the multidimensional anti-aging mechanisms of this ingredient,aiming to provide reference for further research and clinical translational evaluation.

参考文献

[1] JOHNSTONE S E, GLADYSHEV V N, ARYEE M J, et al. Epigenetic clocks,aging, and cancer[J]. Science, 2022, 378(6626):1276-1277.

[2]中华人民共和国中央人民政府.关于印发“十四五”健康老龄化规划的通知[EB/OL].(2022-02-02)[2025-03-01]. https://www.gov.cn/gongbao/content/2022/content_5692863.htm.

[3] MOSKALEV A, GUVATOVA Z, LOPES I A, et al. Targeting aging mechanisms:pharmacological perspectives[J]. Trends Endocrinol Metab,2022, 33(4):266-280.

[4] L〇PEZ-OTíN C, BLASCO M A, PARTRIDGE L, et al. Hallmarks of aging:An expanding universe[J]. Cell, 2023, 186(2):243-278.

[5] CAMPISI J, KAPAHI P, LITHGOW G J, et al. From discoveries in ageing research to therapeutics for healthy ageing[J]. Nature, 2019, 571(7764):183-192.

[6] ZHANG L, PITCHER L E, PRAHALAD V, et al. Targeting cellular senescence with senotherapeutics:senolytics and senomorphics[J]. FEBS J,2023, 290(5):1362-1383.

[7]曾凡沐辰,叶贤龙,于伟,等.基于Cite Space和VOSviewer的药食同源中药抗衰老研究进展可视化分析[J].中草药, 2024, 55(22):7786-7798.

[8] DING X, MA X, MENG P, et al. Potential effects of traditional chinese medicine in anti-aging and aging-related diseases:current evidence and perspectives[J]. Clin Interv Aging, 2024, 19:681-693.

[9]张春彬,李琳,康茜,等. HPLC一测多评法测定泽泻饮片中6种三萜类成分的含量[J].华西药学杂志, 2023, 38(1):79-83.

[10]国家药典委员会.中华人民共和国药典:一部[S].北京:中国医药科技出版社, 2020:239-240.

[11]刘珊珊,魏守辉,朱晶晶,等.泽泻的本草考证、原植物调查及DNA条形码鉴定研究[J].中国中药杂志, 2020, 45(7):1536-1544.

[12] ZHANG T, ZHANG F, ZHANG Y, et al. The roles of serine hydrolases and serum albumin in alisol B 23-acetate hydrolysis in humans[J]. Front Pharmacol, 2023, 14:1160665.

[13] ANSARI K N. The free radicals--the hidden culprits--an update[J]. Indian J Med Sci, 1997, 51(9):319-336.

[14] HUANG L, SHI L, LI M, et al. Oxidative stress in endometriosis:Sources,mechanisms and therapeutic potential of antioxidants(Review)[J]. Int J Mol Med, 2025, 55(5):72.

[15] LI B, MING H, QIN S, et al. Redox regulation:mechanisms, biology and therapeutic targets in diseases[J]. Signal Transduct Target Ther, 2025, 10(1):72.

[16] JACQUES C E, DONIDA B, MESCKA C P, et al. Oxidative and nitrative stress and pro-inflammatory cytokines in Mucopolysaccharidosis type II patients:effect of long-term enzyme replacement therapy and relation with glycosaminoglycan accumulation[J]. Biochim Biophys Acta, 2016, 1862(9):1608-1616.

[17] ZHANG L, LIN W, CAI Y, et al. Farnesoid X receptor activation is required for the anti-inflammatory and anti-oxidative stress effects of Alisol B23-acetate in carbon tetrachloride-induced liver fibrosis in mice[J]. Int Immunopharmacol, 2023, 123:110768.

[18] KASPAR J W, JAISWAL A K. Antioxidant-induced phosphorylation of tyrosine 486 leads to rapid nuclear export of Bach1 that allows Nrf2 to bind to the antioxidant response element and activate defensive gene expression[J]. J Biol Chem, 2010, 285(1):153-162.

[19] LEVINGS D C, WANG X, KOHLHASE D, et al. A distinct class of antioxidant response elements is consistently activated in tumors with NRF2mutations[J]. Redox Biol, 2018,19:235-249.

[20] LIU T, ZHANG L, JOO D, et al. NF-κB signaling in inflammation[J]. Signal Transduct Target Ther, 2017, 2:17023.

[21] HENEKA M T, CARSON M J,KHOURY J, et al. Neuroinflammation in Alzheimer's disease[J]. Lancet Neurol, 2015, 14(4):388-405.

[22] FRANCESCHI C, CAMPISI J. Chronic inflammation(inflammaging)and its potential contribution to age-associated diseases[J]. J Gerontol A Biol Sci Med Sci, 2014, 69(1):S4-S9.

[23] LI X, LI C, ZHANG W, et al. Inflammation and aging:signaling pathways and intervention therapies[J]. Signal Transduct Target Ther, 2023, 8(1):239.

[24] YOUSEFZADEH M J, FLORES R R, ZHU Y, et al. An aged immune system drives senescence and ageing of solid organs[J]. Nature, 2021, 594(7861):100-105.

[25] SUN E, TORICES S, OSBORNE O M, et al. Microvascular dysfunction,mitochondrial reprogramming, and inflammasome activation as critical regulators of ischemic stroke severity induced by chronic exposure to prescription opioids[J]. J Neurosci, 2025, 45(8):e0614242024.

[26] FU Y, FENG H, DING X, et al. Alisol B 23-acetate adjusts bile acid metabolisim via hepatic FXR-BSEP signaling activation to alleviate atherosclerosis[J]. Phytomedicine, 2022, 101:154120.

[27]赵彩娇,卢美静,蒋云芳,等.灵龟八法对衰老大鼠IL-10、IFN-γ活性及基因表达的影响[J].针灸临床杂志, 2019, 35(4):43-46.

[28]王重阳,李奇玮,姜北,等.何首乌延缓衰老机制探析[J].辽宁中医药大学学报, 2024, 26(9):177-181.

[29] SHAO C, FU B, JI N, et al. Alisol B 23-acetate inhibits Ig E/Ag-mediated mast cell activation and allergic reaction[J]. Int J Mol Sci, 2018, 19(12):4092.

[30] NAM K H, IM D S. Alisol B 23-Acetate ameliorates ovalbumin-induced allergic asthma during sensitization and challenge periods[J]. Biomol Ther(Seoul), 2023, 31(6):611-618.

[31] GOHLKE S, ZAGORIY V, CUADROS I A, et al. Identification of functional lipid metabolism biomarkers of brown adipose tissue aging[J]. Mol Metab,2019, 24:1-17.

[32] JIA G, JIA Y, SOWERS J R. Contribution of maladaptive adipose tissue expansion to development of cardiovascular disease[J]. Compr Physiol, 2016,7(1):253-262.

[33] BHARATH L P, IP B C, NIKOLAJCZYK B S. Adaptive immunity and metabolic health:harmony becomes dissonant in obesity and aging[J]. Compr Physiol, 2017, 7(4):1307-1337.

[34] CHEN Q, CHAO Y, ZHANG W, et al. Activation of estrogen receptor α(ERα)is required for Alisol B 23-acetate to prevent post-menopausal atherosclerosis and reduced lipid accumulation[J]. Life Sci. 2020, 258:118030.

[35] XU F, YU H, LU C, et al. The cholesterol-lowering effect of alisol acetates based on HMG-Co A reductase and its molecular mechanism[J]. Evid Based Complement Alternat Med, 2016, 2016:4753852.

[36] BOYARINTSEV D,KUZMINOV I,ORLOVA M. New aspects in the mechanism of action of 3-hydroxy-3-methylglutaryl-COA reductase(HMGCo A reductase):cyclic lactones-potential inhibitors of the enzyme(review)[J].Current Enzyme Inhibition, 2024, 20(3):164-172.

[37] YU X C, FU Y, BI Y H, et al. Alisol B 23-acetate activates ABCG5/G8 in the jejunum via the LXRα/ACAT2 pathway to relieve atherosclerosis in ovariectomized Apo E-/-mice[J]. Aging(Albany NY), 2020, 12(24):25744-25766.

[38] SALMINEN A, OJALA J, KAARNIRANTA K. Apoptosis and aging:increased resistance to apoptosis enhances the aging process[J]. Cell Mol Life Sci, 2011, 68(6):1021-1031.

[39] BERTHELOOT D, LATZ E, FRANKLIN B S. Necroptosis, pyroptosis and apoptosis:an intricate game of cell death[J]. Cell Mol Immunol, 2021, 18(5):1106-1121.

[40] D'IPPOLITO G, HOWARD G A, ROOS B A, et al. Sustained stromal stem cell self-renewal and osteoblastic differentiation during aging[J]. Rejuvenation Res, 2006, 9(1):10-19.

[41] KHONG S M L, LEE M, KOSARIC N, et al. Single-cell transcriptomics of human mesenchymal stem cells reveal age-related cellular subpopulation depletion and impaired regenerative function[J]. Stem Cells, 2019, 37(2):240-246.

[42] GUDMUNDSRUD R, SKJANES T H, GILMOUR B C, et al. Crosstalk among DNA damage, mitochondrial dysfunction, impaired mitophagy, stem cell attrition, and senescence in the accelerated ageing disorder werner syndrome[J]. Cytogenet Genome Res, 2021, 161(6/7):297-304.

[43] DESAI S, JAYASURIYA C T. Implementation of endogenous and exogenous mesenchymal progenitor cells for skeletal tissue regeneration and repair[J]. Bioengineering(Basel), 2020, 7(3):86.

[44] WANG J, LI H, WANG X, et al. Alisol B-23-acetate, a tetracyclic triterpenoid isolated from Alisma orientale, induces apoptosis in human lung cancer cells via the mitochondrial pathway[J]. Biochem Biophys Res Commun, 2018, 505(4):1015-1021.

[45] LIU Y, XIA X C, MENG L Y, et al. Alisol B 23 acetate inhibits the viability and induces apoptosis of nonsmall cell lung cancer cells via PI3K/AKT/m TOR signal pathway[J]. Mol Med Rep, 2019, 20(2):1187-1195.

[46] JANG E, LEE J H. Promising anticancer activities of alismatis rhizome and its triterpenes via p38 and PI3K/Akt/m TOR signaling pathways[J]. Nutrients,2021, 13(7):2455.

[47] MENG Q, CHEN X, WANG C, et al. Alisol B 23-acetate promotes liver regeneration in mice after partial hepatectomy via activating farnesoid X receptor[J]. Biochem Pharmacol, 2014, 92(2):289-298.

[48] NAKAMURA S, HIRANO I, OKINAKA K, et al. The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia[J]. Carcinogenesis, 2010,31(11):2012-2021.

[49] ALDAALIS A, BENGOECHEA-ALONSO M T, ERICSSON J. The SREBPdependent regulation of cyclin D1 coordinates cell proliferation and lipid synthesis[J]. Front Oncol, 2022,12:942386.

[50] FARSHADI E, YAN J, LECLERE P, et al. The positive circadian regulators CLOCK and BMAL1 control G2/M cell cycle transition through Cyclin B1[J]. Cell Cycle, 2019, 18(1):16-33.

[51] SLOWEY C, NYHAN D. The vascular system:anatomical, physiological,pathological, and aging considerations[J]. Anesthesiol Clin, 2022, 40(4):557-574.

[52] MIKHED Y, DAIBER A, STEVEN S. Mitochondrial oxidative stress,mitochondrial dna damage and their role in age-related vascular dysfunction[J]. Int J Mol Sci, 2015, 16(7):15918-15953.

[53] DAHLQUIST K J V, CAMELL C D. Aging leukocytes and the inflammatory microenvironment of the adipose tissue[J]. Diabetes, 2022, 71(1):23-30.

[54] ZHOU Y, HILL C, YAO L, et al. Quantitative proteomic analysis in alveolar typeⅡcells reveals the different capacities of RAS and TGF-β to induce epithelialmesenchymal transition[J]. Front Mol Biosci, 2021, 8:595712.

[55] CHEN H, WANG M C, CHEN Y Y, et al. Alisol B 23-acetate attenuates CKD progression by regulating the renin-angiotensin system and gut-kidney axis[J]. Ther Adv Chronic Dis, 2020, 11:2040622320920025.

[56] LUAN Z L, MING W H, SUN X W, et al. A naturally occurring FXR agonist,alisol B 23-acetate, protects against renal ischemia-reperfusion injury[J]. Am J Physiol Renal Physiol, 2021, 321(5):F617-F628.

[57]魏玮,相芳,许诺,等.泽泻不同炮制品中7个化学成分的含量测定[J].中国药师, 2021, 24(12):2284-2288.

[58]张淑敏,仇慧鑫,舒乐新,等.泽泻毒性的古今认识和减毒策略的研究进展[J].中草药, 2024, 55(4):1407-1414.

[59]汪春飞,马良,封亮,等.基于HK-2细胞的泽泻萜类组分体外肾毒性评价及其诱导细胞凋亡作用的探究[J].中国中药杂志, 2016, 41(3):490-497.

[60]姜凯元.泽泻三萜激动法尼酯X受体拮抗千里光碱肝毒性的作用机制研究[D].上海:上海中医药大学, 2021.

[61] DEO S V S, SHARMA J, KUMAR S. Globocan 2020 report on global cancer burden:challenges and opportunities for surgical oncologists[J]. Ann Surg Oncol, 2022, 29(11):6497-6500.

[62] GHATE S R, LI Z, TANG J, et al. Economic burden of adverse events associated with immunotherapy and targeted therapy for metastatic melanoma in the elderly[J]. Am Health Drug Benefits, 2018, 11(7):334-343.

[63] KWON M J, KIM J N, LEE M J, et al. Apoptotic effects of alisol B 23acetate on gastric cancer cells[J]. Mol Med Rep, 2021, 23(4):248.

[64] ZHANG L L, XU Y L, TANG Z H, et al. Effects of alisol B 23-acetate on ovarian cancer cells:G1 phase cell cycle arrest, apoptosis, migration and invasion inhibition[J]. Phytomedicine, 2016, 23(8):800-809.

[65] XIA J, LUO Q, HUANG S, et al. Alisol B 23-acetate-induced Hep G2hepatoma cell death through m TOR signaling-initiated G1 cell cycle arrest and apoptosis:A quantitative proteomic study[J]. Chin J Cancer Res, 2019,31(2):375-388.

基本信息:

DOI:10.13728/j.1673-6427.2025.05.013

中图分类号:R285

引用信息:

[1]张宇,石姗.23-乙酰泽泻醇B抗衰老作用机制的研究进展[J].现代中药研究与实践,2025,39(05):84-89.DOI:10.13728/j.1673-6427.2025.05.013.

基金信息:

2025年中医药事业传承和发展项目(YLB2025ZYYSY01); 2022山东省医药卫生科技发展计划项目(202216000995); 山东中医药大学附属医院第三批朝阳人才项目(zyrc-2024-22)

投稿时间:

2025-03-10

投稿日期(年):

2025

修回时间:

2025-04-17

终审时间:

2025-04-25

终审日期(年):

2025

审稿周期(年):

1

发布时间:

2025-10-28

出版时间:

2025-10-28

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