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2025 02 v.39 32-37
基于网络药理学探讨加味逍遥散治疗卒中后抑郁的作用机制
基金项目(Foundation): 黑龙江省卫生健康委基金项目(20222121020662); 黑龙江中医药大学研究生创新科研项目(2023yjscx026)
邮箱(Email): jbhzf8224099@163.com;
DOI: 10.13728/j.1673-6427.2025.02.006
中文作者单位:

中国医学科学院药用植物研究所云南分所检测中心;黑龙江中医药大学药物安全性评价中心;西双版纳柬龙制药有限公司科创中心;

摘要(Abstract):

目的 研究加味逍遥散治疗卒中后抑郁的作用机制。方法 采用网络药理学技术搜集并筛选加味逍遥散治疗卒中后抑郁的关键靶点及信号通路,并结合体内药效实验验证加味逍遥散治疗卒中后抑郁的作用。结果 网络药理学筛选出关键靶点1 489个、20条GO富集分析及20条KEGG信号通路,结果显示核心靶点和信号通路与炎症反应及NF-κB信号通路密切相关。结论 加味逍遥散能改善卒中后抑郁大鼠的抑郁样行为,其作用机制可能与减轻卒中后抑郁模型大鼠炎症反应,抑制大鼠海马区NF-κB p65蛋白的表达有关。

关键词(KeyWords): 加味逍遥散;卒中后抑郁;网络药理学;炎症反应;NF-κB
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基本信息:

DOI:10.13728/j.1673-6427.2025.02.006

中图分类号:R285.5

引用信息:

[1]袁茵,王添,刘金雨等.基于网络药理学探讨加味逍遥散治疗卒中后抑郁的作用机制[J].现代中药研究与实践,2025,39(02):32-37.DOI:10.13728/j.1673-6427.2025.02.006.

基金信息:

黑龙江省卫生健康委基金项目(20222121020662); 黑龙江中医药大学研究生创新科研项目(2023yjscx026)

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